Protective effect of Nigella sativa oil and Astaxanthin on Monosodium glutamate Induced dyslipidemia in Rats

The present study was aimed to evaluate the possible ameliorative effect ofNigella sativa oil(NSO) andAstaxanthin(ASX) against Monosodium glutamate(MSG) (0.8g/Kg b.wt) induced dyslipidemia in rats. Forty eightpubertal male albino rats were divided into eight groups consisting of six each. Rats of groups 2, 3 and 4 were treated with MSG (0.8g/Kg b.wt), NSO (1ml/Kg b.wt) and ASX (25mg/Kg b.wt) orally for 28 days, respectively. Further, rats of groups 5, 6, 7 and 8 were coadministered with NSO + ASX, MSG + NSO, MSG + ASX and MSG + NSO + ASX orally, respectively. At the end of the experimentation, the blood samples were collected and the serum was used for biochemical analysis.Administration of MSG elevated the concentration of Total Cholesterol (TC),Triglycerides (TG),Low density lipoprotein (LDL) and Very low density lipoprotein (VLDL) with a decreased level of High density lipoprotein (HDL) in the serum of male albino rats, compared to control (group 1). However, the concentration of all lipids in the serum was restored to normalcy in rats treated withNSO + MSG (group – 6),ASX + MSG (group-7),MSG + NSO+ ASX (group – 8), No significant change was observed in the Lipid profile in the serum of rats received NSO (group – 3), ASX (group – 4) alone and combination of NSO with ASX (group – 5). The results indicate the protective effect of NSO and ASX in the serum lipid profile in the MSG induced toxicity in male pubertal albino rats.